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PCOS (Polycystic Ovary Syndrome) – Causes, Symptoms & Treatment

By Dr Arun Muthuvel MBBS, MS, MCh – Reproductive Medicine & Surgery · January 15, 2025

Illustration of an ovary with follicles representing PCOS

Polycystic Ovary Syndrome (PCOS) is one of the most common hormonal disorders affecting women of reproductive age. It is estimated to affect around 8–13% of women worldwide, and it remains a leading cause of infertility. Despite its prevalence, many women go undiagnosed for years.

PCOS treatment with Dr. Arun Muthuvel in Chennai

Dr. Arun Muthuvel is an MCh-qualified reproductive medicine and surgery specialist in Chennai who treats PCOS as a metabolic and hormonal condition, not simply an ovulation problem. Most women with PCOS conceive, often with straightforward treatment, and the majority never need IVF.

PCOS also requires careful handling during IVF because these ovaries respond strongly to stimulation and carry a higher risk of ovarian hyperstimulation syndrome. Dr. Arun Muthuvel uses antagonist protocols, agonist triggers and freeze-all strategies to keep PCOS treatment both effective and safe.

What is PCOS?

PCOS is a condition in which the ovaries produce an excess of androgens (male hormones), leading to irregular menstrual cycles, the formation of small fluid-filled sacs (follicles) in the ovaries, and difficulty in releasing eggs regularly. This hormonal imbalance can affect ovulation and make it harder to conceive.

Common Symptoms

Causes and Risk Factors

The exact cause of PCOS is not fully understood, but several factors play a role. Genetics is a significant contributor – women with a mother or sister with PCOS are more likely to develop it. Insulin resistance is another key factor, as elevated insulin levels can stimulate the ovaries to produce more androgens. Obesity can worsen insulin resistance and amplify symptoms.

How PCOS Affects Fertility

PCOS is one of the most common causes of anovulatory infertility. When ovulation does not occur regularly, the chances of natural conception decrease significantly. However, with appropriate medical intervention, the majority of women with PCOS can achieve a successful pregnancy.

Treatment Options

Treatment for PCOS depends on the individual’s symptoms, age, and whether she is trying to conceive. Common approaches include:

When to See a Specialist

How PCOS Is Diagnosed

Diagnosis uses the Rotterdam criteria, which require two of the following three features once other conditions have been excluded:

  1. Irregular or absent ovulation, usually showing as cycles longer than 35 days or fewer than eight periods a year.
  2. Clinical or biochemical hyperandrogenism, meaning excess hair growth, acne or hair thinning, or raised testosterone on a blood test.
  3. Polycystic ovarian morphology on ultrasound, with 20 or more small follicles in an ovary or an increased ovarian volume.

Thyroid disease, high prolactin, congenital adrenal hyperplasia and Cushing syndrome must be excluded first, since each can imitate PCOS. Ultrasound alone never makes the diagnosis, and many women have polycystic-looking ovaries without the syndrome.

Stepwise Fertility Treatment

StepTreatmentNotes
1Weight and lifestyle managementA 5 to 10 percent weight loss restores ovulation in many women
2LetrozoleFirst-line ovulation induction; higher live birth rates than clomiphene in PCOS
3Clomiphene citrateEffective alternative where letrozole is unsuitable
4MetforminAdded for insulin resistance or with letrozole in selected women
5Gonadotrophin injectionsLow-dose protocols with close monitoring to avoid multiple pregnancy
6Laparoscopic ovarian drillingAn option in clomiphene-resistant PCOS, used selectively
7IVF or ICSIFor those who do not conceive with the above, or with other factors present

PCOS Beyond Fertility

PCOS carries long-term risks that deserve attention regardless of whether a woman is trying to conceive: type 2 diabetes, high cholesterol, fatty liver, high blood pressure, sleep apnoea, endometrial hyperplasia from infrequent periods, and a higher rate of anxiety and depression.

Women with PCOS also have a higher risk of gestational diabetes and pre-eclampsia in pregnancy, so early screening is arranged. Weight is central to almost every aspect of the condition, and our guide to weight gain and PCOS explains why the relationship runs in both directions.

Frequently Asked Questions

Can I get pregnant naturally with PCOS?

Yes. Many women with PCOS conceive naturally, particularly after weight loss restores regular ovulation. Where cycles remain irregular, ovulation induction with letrozole is highly effective.

Is letrozole better than clomiphene for PCOS?

In PCOS, letrozole produces higher ovulation and live birth rates than clomiphene and is recommended as first-line treatment by international guidelines.

Do I need IVF for PCOS?

Usually not. IVF is reserved for women who do not conceive with ovulation induction or who have an additional factor such as tubal disease or severe male factor.

Does PCOS go away after pregnancy?

No, but symptoms often change over time. Cycles may become more regular approaching the forties, and weight management continues to improve both symptoms and long-term health.

Why consult Dr. Arun Muthuvel for PCOS in Chennai?

He manages PCOS as a whole-body condition, starts with the least invasive effective treatment, and uses hyperstimulation-safe protocols when IVF is genuinely needed.

The Bottom Line

PCOS is the most common cause of ovulation problems and one of the most treatable. Dr. Arun Muthuvel provides stepwise PCOS fertility treatment in Chennai, from weight and metabolic management through letrozole ovulation induction to safely conducted IVF.

This article provides general medical information and does not replace individual diagnosis or treatment advice. Outcomes vary with age, diagnosis, test results and clinical circumstances.

Our Fertility Specialists Are Here To Help

Consult Dr Arun Muthuvel, MS (OBGYN), MCh (Reproductive Medicine & Surgery), for personalised fertility and IVF care in Chennai.

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