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Varicocele and Male Infertility – Impact on Sperm Production

By Dr Arun Muthuvel MBBS, MS, MCh – Reproductive Medicine & Surgery · June 05, 2025

Varicocele is one of the most common and correctable causes of male infertility. It refers to the abnormal enlargement of veins within the scrotum, similar to varicose veins in the legs. Varicoceles are found in about 15% of the general male population and in up to 40% of men evaluated for infertility.

What Is a Varicocele?

A varicocele develops when the valves inside the veins of the spermatic cord fail to function properly, causing blood to pool and the veins to dilate. It most often occurs on the left side due to anatomical differences in venous drainage. Varicoceles typically form during puberty and usually develop gradually over time.

How Varicocele Affects Fertility

The pooling of blood increases the temperature around the testicles, impairing the optimal environment required for sperm production. This leads to reduced sperm count, motility, and abnormal morphology. Varicocele is also associated with increased oxidative stress and higher sperm DNA fragmentation, both of which can lower natural conception rates and affect outcomes of assisted reproduction.

Symptoms

Diagnosis

Diagnosis typically begins with a physical examination, often performed while the patient is standing and performing the Valsalva manoeuvre. A scrotal ultrasound with Doppler study confirms the diagnosis and helps grade the severity. A semen analysis is always performed to assess the impact on sperm parameters.

Treatment Options

Treatment is generally recommended when the varicocele is associated with infertility, abnormal semen parameters, or bothersome symptoms. Options include:

Outcomes After Treatment

Studies show that varicocele repair leads to improvement in semen parameters in 60–70% of men, with spontaneous pregnancy rates improving significantly within 6–12 months. Even in men who still require IVF or ICSI, varicocele repair can improve sperm DNA quality and treatment outcomes.

If you have been diagnosed with a varicocele or are facing fertility concerns, a reproductive medicine specialist can help determine whether treatment will benefit your chances of conception.

Our Fertility Specialists Are Here To Help

Consult with Dr Arun Muthuvel MS, MCh who is a specialist in Azoospermia at Iswarya Fertility centres in Chennai, India.

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